INDICATIONS: Treatment of systemic fungal infections such as blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. Its use is restricted to cases where safer and more effective alternatives are not available, or when, after evaluating the patient, the benefits outweigh potential risks. Treatment of Cushing’s syndrome in cases where no other alternatives exist, under strict medical supervision.

DOSAGE: Administered orally, 200 mg once daily, taken with food to increase absorption and reduce gastrointestinal discomfort. The dose may be increased to 400 mg daily if an adequate response is not achieved.

Pediatric Patients: Children over 2 years: recommended 3 mg per kg of body weight per day.

CONTRAINDICATIONS: Micosin® is contraindicated in patients hypersensitive to this medication. Co-administration of ketoconazole with astemizole, cisapride, corticosteroids, triazolam, cyclosporine, oral anticoagulants, and terfenadine is contraindicated. Its use is not recommended during pregnancy and lactation.

PRECAUTIONS: Liver function tests are recommended before starting treatment and periodically during therapy. Concomitant use with hepatotoxic substances such as alcohol and paracetamol should be avoided. A disulfiram-like reaction may occur in patients taking ketoconazole after consuming alcohol. The effectiveness of oral contraceptives may be reduced.

INTERACTIONS: Ketoconazole inhibits the metabolism of a number of drugs by acting on the CYP3A4 isoenzyme of the hepatic microsomal P450 system. This leads to increased plasma levels of terfenadine, prolonging the QT interval. Similarly, it reduces the clearance of astemizole, which may cause arrhythmias, tachycardia, cardiac arrest, and death. Astemizole should be discontinued at least one week before starting ketoconazole therapy. Ketoconazole reduces the clearance of cisapride; concomitant use has been associated with QT prolongation and torsades de pointes. Ketoconazole can induce disulfiram-like reactions; alcohol should be avoided during treatment and for at least 48 hours after discontinuation. Concomitant administration of ketoconazole and indinavir increases the antiviral’s AUC by 68%. Ketoconazole dramatically inhibits the hepatic metabolism of triazolam and midazolam; simultaneous use should be avoided. Other benzodiazepines affected include alprazolam and estazolam. Ketoconazole requires an acidic gastric pH for absorption; drugs that reduce gastric acid secretion or alkalinize the stomach significantly reduce its bioavailability, including antacids, antimuscarinics, H2 antihistamines, and proton pump inhibitors. Sucralfate also reduces ketoconazole absorption by 20%. Ketoconazole may decrease the clearance of corticosteroids such as prednisolone and methylprednisolone, increasing plasma concentrations. It also increases cyclosporine plasma levels. Ketoconazole can reduce the clearance of calcium channel blockers (e.g., diltiazem, felodipine, verapamil) by inhibiting CYP3A4 metabolism. Concomitant use with tacrolimus may increase tacrolimus blood levels. Co-administration with ritonavir results in 3–4 fold increases in ketoconazole concentrations; therefore, doses >200 mg/day are not recommended with ritonavir.

PREGNANCY AND LACTATION: Preclinical data indicate that ketoconazole crosses the placenta and is teratogenic. It should only be used during pregnancy when the therapeutic need for the mother outweighs the risk to the fetus. As ketoconazole is excreted in breast milk, breastfeeding should be discontinued during treatment.

ADVERSE REACTIONS: Nausea, vomiting, and abdominal pain have been reported; these are usually mild and can be minimized if the drug is taken with food, which also improves bioavailability. Rarely, hepatotoxicity occurs. These effects are reversible upon discontinuation of treatment.

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CONTRAINDICATIONS
Hypersensitivity to horse chestnut.

PRECAUTIONS FOR USE
In case of unsatisfactory or inadequate response, after six weeks, you should consult your doctor to rule out other probable causes of edema.
Do not use in children, pregnancy and lactation.
COMPOSITION
• Venostasin Retard Capsules Horse Chestnut Extract (Equivalent to Escin 50Mg) 300mg
• Venostasin Tablets ß Escin Cas N° (6805-41-0) 0.0150g
• Venostasin Gel – Each 100gr of gel contains: ß Escin 1g – Ethinyl Glycolic MonoSalicylic Acid Ester 5g – Sodium Heparin 5,000UI
**If symptoms persist consult your doctor

Vitafem Benefits and indications:

Genistein is a naturally occurring isoflavone.

The Genistein contained in Vitafem helps with sudden mood changes including irritability, anxiety and depression.

The Biotin that is in the composition of Vitafem is important for the healthy structure of the skin, hair and nails.

The Genistein present in Vitafem prevents hot flashes, sweating and weakness present during menopause,

Vitafem’s Genistein together with Calcium and vitamin D3 promote bone metabolism. Calcium is the most important mineral in the body and vitamin D3 is important for its absorption.

Genistein reduces cardiovascular risk due to its powerful antioxidant effect

Vitamin B1 is essential for nerve metabolism.

Vitamin B2 is important for cellular respiration.

Folic acid, together with the B complex vitamins, is particularly important for the structure of proteins and the formation of red and white blood cells, involved in the transport of oxygen in the process of cell division and renewal.

DOSAGE

One tablet a day, take it orally with a sufficient amount of liquid.

SIDE EFFECTS

Gastrointestinal effects such as nausea have been reported rarely.

INTERACTIONS

They have not been reported to date.

COMPOSITION

• Genistein 50mg

• Calcium 500mg

• Cholecalciferol (Vit. D3) 200UI

• Biotin 0.15mg

• Thiamine (Vit. B1) 1.40mg

• Riboflavin (Vit. B2) 1.60mg

• Folic Acid 0.40mg

**If symptoms persist consult your MD

COMPOSITION: Each coated tablet contains Paracetamol 500 mg, Excipients.

INDICATIONS: Paracetamol is an effective analgesic and antipyretic for the control of mild or moderate pain caused by joint disorders, ear pain, headaches, odontogenic pain, neuralgia, minor surgical procedures, etc.

It is also effective for the treatment of fever such as that caused by viral infections, post-vaccination fever, etc.

DOSE: Adults: The usual dose for analgesia and fever control is 325 to 1,000 mg every four hours, up to a maximum of 4 grams per day.

In patients with renal insufficiency, it is recommended to increase the administration interval to six hours, as in patients with moderate renal damage, and to eight hours in patients whose glomerular filtration rate is less than 10ml/min.

In case of hepatic insufficiency, 2g/24 hours will not be exceeded and the minimum interval between doses will be 8 hours.

Pregnancy and Lactation: Corresponds to pregnancy risk category B, its non-prolonged use is considered safe during the three trimesters of pregnancy.

It is compatible with lactation.

CONTRAINDICATIONS and PRECAUTIONS:

Hypersensitivity to acetaminophen, because it is metabolized in the liver, it should be administered with caution in patients with liver damage, as well as in those who are receiving hepatotoxic drugs or who have some type of nephropathy.

The risk of hepatotoxicity is rather high in patients with alcohol dependence and in patients receiving more than one medication containing acetaminophen.

Avoid the use of high doses in patients with hepatic dysfunction.

Avoid use in patients with phenylketonuria or G6PD deficiency.

Use with caution in patients with dehydration or chronic malnutrition. Self-medication with paracetamol should be limited when being treated with anticonvulsants, since it enhances hepatoxicity and decreases the bioavailability of paracetamol.

COMPOSITION: Each coated tablet contains:

Calcium 400 mg, Iron 18 mg, Vitamin D 10 µg, Folic Acid 400 µg.

INDICATIONS: Flexa® NATAL FORTE in combination with regular exercise and a balanced diet with sufficient calcium helps women, especially pregnant women, to maintain good bone health, contributes to normal bone maintenance, with adequate intakes of folic acid, can reduce the risk a woman from having a child with a spinal or brain defect, in combination with a diet rich in iron, promotes normal development and cognitive function, with an adequate supply of oxygen, in addition to normal cell division.

This food is a source of: Calcium, Vitamin D, Folic Acid and Iron.

DOSE: Pregnant women and lactating women are recommended to take one tablet with breakfast.

CONTRAINDICATIONS and PRECAUTIONS:

This product is not suitable to be consumed as the only food source.

Do not exceed the recommended dose.

If you are taking any medication, consult your doctor before taking this product.

Oral suspension 400 mg/80 mg /5mL: 120 mL bottle + measuring spoon.

COMPOSITION:

Each coated tablet contains: Trimethoprim 160 mg and Sulfamethoxazole 800 mg. (CO-TRIMOXAZOLE).

Each 5 mL teaspoon contains:

trimethoprim 80 mg and sulfamethoxazole 400 mg. (CO-TRIMOXAZOLE)

INDICATIONS: Broad-spectrum chemobactericide, recommended for: Acute and chronic infections of the urinary tract, caused by E. coli, P. mirabilis or Klebsiella pneumoniae. Prophylaxis in women with multiple reinfections

Acute and chronic bacterial prostatitis.

Acute gastroenteritis, caused by Salmonella, Shigella and E. coli.

Typhoid, including resistant to chloramphenicol and ampicillin.

Otitis media and exacerbations of chronic bronchitis, caused by Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.

Pneumocystis carinii pneumonia in patients with AIDS.

DOSE: Meprimforte can be administered with or without food.

The usual dose is one Meprimforte tablet every 12 hours for 7 to 14 days, depending on the infection. In uncomplicated cystitis in women: one tablet every 12 hours for 3 days. In bacterial gastroenteritis: 1 tablet every 12 hours for 5 days. In prevention of recurrences of urinary tract infections ½ tablet 3 times a week for several months.

Dose in adults and children over 12 years: 1 tablet every 12 hours

Dose in children: 8 mg/kg/day of the trimethoprim dose or 40 mg/kg/day of the sulfamethoxazole dose, divided every 12 hours.

CONTRAINDICATIONS AND PRECAUTIONS:

Patients hypersensitive to cotrimoxazole.

Term pregnant women.

Under 2 months of age.

Cotrimoxazole is not recommended during pregnancy or lactation.

It should not be co-administered with metheneamine.

COMPOSITION: Each 5 mL teaspoon contains: Trimethoprim 40 mg and Sulfamethoxazole 200 mg. (CO-TRIMOXAZOLE)

INDICATIONS: The main indications: Acute and chronic infections of the urinary tract, caused by E. coli, P. mirabilis or Klebsiella pneumoniae. Prophylaxis in women with multiple reinfections

Acute and chronic bacterial prostatitis.

Acute gastroenteritis, caused by Salmonella, Shigella and E. coli.

Typhoid, including resistant to chloramphenicol and ampicillin.

Otitis media and exacerbations of chronic bronchitis, caused by Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.

Pneumocystis carinii pneumonia in patients with AIDS.

DOSE: Meprim can be administered with or without food.

Gastrointestinal infections: 40 – 60 / 8 – 10 mg/kg/day divided into 2 doses.

Airway and Urinary Tract Infections: 20 -30 /4 -6 mg/kg/12 hours for 10 days.

CONTRAINDICATIONS and PRECAUTIONS:

Patients hypersensitive to cotrimoxazole.

Term pregnant women.

Under 2 months of age.

Cotrimoxazole is not recommended during pregnancy or lactation.

It should not be co-administered with metheneamine.

COMPOSITION:

Amount per dose (mg / 5 mL):

Micronized Ibuprofen ……………………………… 200,000

Amount (mg / 100 mL):

Micronized Ibuprofen ……………………………… 4000,000

THERAPEUTIC CLASSIFICATION: NSAIDs, non-selective inhibitor of cyclooxygenase.

PROPERTIES:

Ibuprofen is a non-steroidal compound derived from propionic acid with marked anti-inflammatory, analgesic, and antipyretic properties. Its mechanism of action is based on the inhibition of prostaglandin synthesis. Prostaglandins play an essential role in the onset of fever, pain and inflammation. Experimental data suggest that ibuprofen can competitively inhibit the effect of low doses of acetylsalicylic acid on platelet aggregation when administered concomitantly.

INDICATIONS:

• This medicine is indicated in children from 7 years old.

• Symptomatic relief of occasional mild or moderate pain.

• Febrile states.

DOSAGE AND ADMINISTRATION:

Orally. The recommended dose is:

Pediatric population

The dose of ibuprofen to be administered depends on the age and weight of the child. As a rule, the recommended daily dose is 20 to 30 mg / kg of weight, divided into three or four individual doses. As an orientation, the following dosage regimen is recommended:

- Children of 25 to 40 kg of weight (7-12 years approximately): The recommended daily dose is 600 – 800 mg of ibuprofen, divided into 3 or 4 doses (1 on 3 or 4 times a day), the dose being recommended daily maximum 800 mg. – Children over 40 kg and adolescents (over 12 years): The recommended daily dose is 800 -1,200 mg of ibuprofen per day, divided into 3 or 4 doses (1-2 envelopes 3 or 4 times a day ), with a maximum recommended daily dose of 1,200 mg. The use of other presentations with more adequate doses for treatment in adolescents and adults is recommended. The interval between doses will depend on the evolution of the symptoms, but it will never be less than 4 hours.

CONTRAINDICATIONS:

This medicine is contraindicated:

- In patients with hypersensitivity to ibuprofen, to other NSAIDs or to any of the excipients included in the section

- In patients who have experienced asthma attacks, acute rhinitis, urticaria, angioneurotic edema or other allergic-type reactions after using substances with similar action (eg acetylsalicylic acid or other NSAIDs).

- In patients with a history of gastrointestinal hemorrhage or perforation related to previous treatments with NSAIDs. Peptic ulcer / active or recurrent gastrointestinal hemorrhage (two or more different episodes of proven ulceration or bleeding),

- In patients with severe heart failure (NYHA class IV).

- In patients with severe renal dysfunction.

- In patients with severe hepatic dysfunction.

- In patients with hemorrhagic diathesis or other coagulation disorders.

- During the last trimester of pregnancy

WARNING AND PRECAUTIONS:

Gastrointestinal Risks: Gastrointestinal Hemorrhages, Ulcers and Punctures: During treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, gastrointestinal hemorrhages, ulcers and perforations have been reported. Cardiovascular and cerebrovascular risks: Special caution should be exercised in patients with a history of hypertension and / or heart failure, since fluid retention and edema have been reported in association with NSAID treatment. Risks of severe skin reactions: Severe skin reactions, some fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported with very rare frequency in association with the use of NSAIDs. Renal and / or hepatic insufficiency: Ibuprofen should be used with caution in patients with liver or kidney disease and especially during the simultaneous treatment with diuretics, since it should be taken into account that the inhibition of prostaglandin synthesis can cause fluid retention and deterioration of renal function.

PREGNANCY AND LACTATION: contraindicated its use, The inhibition of prostaglandin synthesis, can negatively affect the pregnancy and / or the development of the embryo / fetus

OVERHEADING:

Symptoms due to overdose include: vertigo, spasms, hypotension or depression of the nervous system (reduction of consciousness). If less than one hour has elapsed, a gastric lavage is recommended. The oral intake of substances such as activated charcoal to reduce drug absorption is also considered beneficial. If more than one hour had elapsed, due to the acid nature of the medication, the alkalinization of urine and diuresis is recommended to favor its elimination. In case of intoxication, metabolic acidosis can occur.

REGISTERED PRESENTATIONS:

Box x 1 bottle x 120mL oral suspension + dosing syringe + insert

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